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REVIEW

Implications of Drosophila neuroblast development for tumorigenesis

Yue Yu1,2 ,  Hongsheng Zhu3 ,  Minyan Li1 ,  Xuming Ren1 ,  Lijuan Zhang1 ,  Yu Bai2* ,  Huanping An1,2*
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1 Key Laboratory for Neural Precursor Cell Temporal Regulation and Diseases of Shaanxi Universities, Hanzhong Vocational and Technical College, Hanzhong, Shaanxi 723002, China
2 School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong, Shaanxi 723000, China
3 Department of General Surgery, Chenggu County Hospital, Hanzhong, Shaanxi 723000, China
JBM, e99010082 https://doi.org/10.14440/jbm.0031
Submitted: 8 April 2025 | Revised: 9 September 2025 | Accepted: 10 September 2025 | Published: 9 October 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Background: Tumors are characterized by excessive proliferation and the capacity for metastasis. Understanding the detailed mechanisms of tumor progression is crucial for both tumor prevention and targeted therapy. Drosophila melanogaster neural stem cells, referred to as neuroblasts (NBs), serve as an ideal model for studying tumorigenesis by recapitulating conserved cellular behaviors, signaling pathways, and regulatory mechanisms. NBs possess self-renewal capacity, enabling them to undergo multiple rounds of proliferative divisions, similar to cancer stem cells. Moreover, several signaling pathways and cytokines that regulate NB development also play a critical role in tumorigenesis. For instance, the absence of key factors in NB development, such as Brat and Numb, can lead to tumor formation. Objective: This review focuses on the mechanisms of NB development—including delamination, quiescent NB reactivation, asymmetric cell divisions, and termination—which parallel key tumor processes, such as cell epithelial-mesenchymal transition, stem cell quiescence and reactivation, uncontrolled proliferation, and cell elimination. Conclusion: We summarize recent findings on these tumor progression processes. These insights provide valuable clues for understanding tumor progression and offer potential avenues for tumor prevention and treatment.

Keywords
Neuroblasts
Neuroblast delamination
Quiescent neuroblast reactivation
Neuroblast asymmetric cell divisions
Neuroblast termination
Tumorigenesis
Funding
This work was supported by grants from the Chinese National Natural Science Foundation (32000506) and the Key Laboratory of Shaanxi Universities (20240037).
Conflict of interest
The authors declare no conflicts of interest.
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Journal of Biological Methods, Electronic ISSN: 2326-9901 Print ISSN: TBA, Published by POL Scientific
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