POL Scientific / Bladder / Volume 11 / Issue 2 / DOI: 10.14440/bladder.2024.0014
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RESEARCH ARTICLE

A pilot study on the potential of photobiomodulation to safely modify symptoms of an overactive bladder

Wendy F Bower1* ,  David Michael Whishaw1 ,  Erik Biros2 ,  Christine Baldrey1 ,  Mary P Galea3
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1 Department of Aged Care, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia
2 College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4810, Australia
3 Department of Medicine (Royal Melbourne Hospital), the University of Melbourne, Grattan Street Parkville, Victoria 3010, Australia
Bladder 2024 , 11(2), e21200007; https://doi.org/10.14440/bladder.2024.0014
Submitted: 8 July 2024 | Accepted: 22 August 2024 | Published: 11 September 2024
© 2024 by the Bladder published by POL Scientific. Licensee POL Scientific, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Background: Photobiomodulation (PBM) may stabilize autonomic neural drive from the pontine micturition Center to the urinary bladder in individuals with overactive bladder (OAB) symptoms. Methods: A safety profile study preceded a single-case experimental design with repeated measures across subjects to establish the safety and effect direction of PBM to modify symptoms in patients with OAB. Results: No adverse events occurred with PBM, specifically blood pressure remained unchanged. Urinary frequency improved significantly during the intervention and at follow-up. PBM therapy was associated with a meaningful impact on OAB-related quality of life and a small to medium-to-high effect size on OAB symptom severity. Conclusion: Nasal application of PBM is safe and may impact OAB symptoms. A controlled trial of PBM in patients with lower urinary tract symptoms is warranted.

Keywords
Photobiomodulation
Near-infrared light
Overactive bladder
Incontinence
Urinary urgency
Funding
None.
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Conflict of interest
The authors declare no conflict of interest.
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Bladder, Electronic ISSN: 2327-2120 Print ISSN: TBA, Published by POL Scientific
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